Many studies have explored the effect of free/total prostate-specific antigen (f/t PSA) ratio in monitoring prostate cancer. We conducted a meta-analysis to identify the accuracy of the f/t PSA ratio in the diagnosis of prostate cancer in patients who have PSA levels of 4 to 10 ng/mL.
Complexed PSA: This test directly measures the amount of PSA that is attached to other proteins (the portion of PSA that is not "free"). This test could be done instead of checking the total and free PSA, and it could give the same amount of information, but it is not widely used.
Correlation between the complex PSA/total PSA ratio and the free PSA/total PSA ratio, sensitivity and specificity of both markers for the diagnosis of prostate cancer Correlación del cociente PSA complex/PSA total con el cociente PSA libre/PSA total, sensibilidad y especificidad de ambos marcadores para el diagnóstico del cáncer de prostata☆
This finding has been exploited in the use of the ratio of free to total PSA and complexed PSA (cPSA) as a means of distinguishing between prostate cancer and BPH as a cause of an elevated PSA. (See 'Serum free and bound PSA' below and 'Complexed PSA' below.)
Over the past years, the assessment of equimolarity has been typically performed by the characterization of the recovery of IS 96/670, consisting of 90% PSA-ACT and 10% PSA free form, by marketed PSA assays.
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complexed psa vs free psa
